Pharmacologic blockade of MCH-R1 receptor reduces cataplexy and REM sleep in narcoleptic mice
نویسندگان
چکیده
منابع مشابه
Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.
Recent work has implicated the hypocretin (orexin) system in the genesis of narcolepsy. In the current study we demonstrate that systemically administered hypocretin-1 (Hcrt-1) produces an increase in activity level, longer waking periods, a decrease in REM sleep without change in nonREM sleep, reduced sleep fragmentation and a dose dependent reduction in cataplexy in canine narcoleptics. Repea...
متن کاملChallenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation.
STUDY OBJECTIVES We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this hypothesis, we investigated the effect of physiologically intensified NREMS in recovery sleep following sleep deprivation. DESIGN Nocturnal baseline and recovery sleep architecture, and the sleep e...
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The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta. MCHergic neurons project throughout the central nervous system, including areas such as the dorsal (DR) and median (MR) raphe nuclei, which are involved in the control of sleep and mood. Major Depression (MD) is a prevalent psychiat...
متن کاملREM sleep respiratory behaviours mental content in narcoleptic lucid dreamers
Breathing is irregular during rapid eye-movement (REM) sleep, whereas it is stable during non-REM sleep. Why this is so remains a mystery. We propose that irregular breathing has a cortical origin and reflects the mental content of dreams, which often accompany REM sleep. We tested 21 patients with narcolepsy who had the exceptional ability to lucid dream in REM sleep, a condition in which one ...
متن کاملActivity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.
Narcolepsy has been hypothesized to be a disease of rapid eye movement (REM) sleep. According to this hypothesis, cataplexy is a result of the triggering during waking of the mechanism that normally serves to suppress muscle tone in REM sleep. REM sleep control mechanisms have been localized to the pons. Narcoleptic dogs have increased numbers of cholinergic receptors in the medial pons. These ...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2011
ISSN: 1662-453X
DOI: 10.3389/conf.fnins.2011.84.00143